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It also promoted its executive vice president of research and development, Norbert W. Bischofberger, to chief scientific officer.
Both have been with the Foster City biopharmaceutical company since 1990.
Gilead said Milligan will continue to serve as chief financial officer until a successor is found.
It said Bischofberger will oversee all aspects of its R&D, including Gilead's recently acquired Seattle, Wash., and Westminster, Colo., programs in the fields of respiratory and cardiopulmonary therapeutics and the company's Edmonton, Alberta operations.