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The deal values Matrix, which ranks about No. 7 by market value among India's top pharmaceuticals companies, at more than $1 billion and about 22 times expected earnings, compared with a Indian drugs sector average of 18.
Mylan said Matrix will expose it to important emerging markets including India, China and Africa, and give it a European footprint and distribution network through Matrix's Docpharma subsidiary.
But Bank of America analyst David Maris called the deal expensive and possibly problematic in a research note.
"It appears that Mylan is paying $736 million for a company that had approximately $23 million in free cash flow last fiscal year -- a high price in our opinion," Maris said.
Matrix manufactures active pharmaceutical ingredients and solid oral dosage forms.